Mixing MAOIs and Methylphenidate (Ritalin)

Dangerous

MAOIs can make amphetamines far stronger and longer-lasting, and can cause a dangerous spike in blood pressure.

Do this

Do not combine.

General answer for Amphetamines: nothing specific to these two is documented.

Where the risk isTap for why
In an emergency, call 911911Never Use AlonePoison Control
What to do
  • Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
  • Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
  • Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
  • Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
  • Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means

High risk of death or life-changing injury. Do not combine.

How the ratings work
The longer explanation

MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive crises.

Sources (1)

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Other names
MAOIs
maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
Methylphenidate
ritalin, ritalin la, concerta, focalin, dexmethylphenidate, methylin
Not an amphetamine, but mixes much like one — most answers here are Adderall's
Also searched asmaois and Ritalin, maois and ritalin la
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Related combinations

MAOIs withWhat not to mix with MAOIs →
Methylphenidate withWhat not to mix with Methylphenidate →
All combinations →

Can you mix MAOIs and Methylphenidate (Ritalin)?

MixSafe rates mixing MAOIs and Methylphenidate as "Dangerous" — high risk of death or life-changing injury. Do not combine. No interaction specific to MAOIs and Methylphenidate is documented; this is the default for Amphetamines. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Amphetamines. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.