Substance
What not to mix with MAOIs
AntidepressantDrug class
Also calledmaoi, nardil, phenelzine, parnate, tranylcypromine, marplan
Summary
MAOIs is checked against 40 other substances — 12 dangerous, 3 unsafe and 13 caution.
Dangerous
12- MAOIs and 5-MeO-xxTHigh risk of death or life-changing injury. Do not combine.
- MAOIs and AmphetaminesMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive…
- MAOIs and AMTaMT is an MAOI on its own. Using enzyme inhibitors can greatly reduce predictability of effects.
- MAOIs and CocaineThis combination is poorly explored
- MAOIs and DXMHigh risk of serotonin syndrome
- MAOIs and KratomMitragynine has monoamine activity and MAOIs block the breakdown of exactly what it releases. Hypertensive and serotonergic reactions are both…
- MAOIs and MDMAMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with MDMA will lead to hypertensive crises.
- MAOIs and MephedroneMephedrone releases serotonin, dopamine and noradrenaline. With an MAOI blocking their breakdown, this risks hypertensive crisis and serotonin…
- MAOIs and MethamphetamineMethamphetamine releases noradrenaline, dopamine and serotonin; an MAOI prevents their breakdown. Hypertensive crisis and serotonin syndrome are both…
- MAOIs and PCPThis combination is very poorly explored
- MAOIs and SSRIsHigh risk of death or life-changing injury. Do not combine.
- MAOIs and TramadolHigh risk of death or life-changing injury. Do not combine.
Unsafe
3- MAOIs and AlcoholTyramine found in many alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.
- MAOIs and DiphenhydramineThere is a significant risk of serotonin syndrome with this combination. Monoamine oxidase A inhibitors may extend and increase the anticholinergic…
- MAOIs and MXEMAO-B inhibitors appear to increase the potency of MXE. MAO-A inhbitors have some negative reports associated with the combination but there isn't…
Caution
13- MAOIs and 2C-T-xMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably, which could be dangerous given the unpredictability of the…
- MAOIs and 2C-xMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably
- MAOIs and BuprenorphineCoadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse…
- MAOIs and CodeineCoadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse…
- MAOIs and DOxMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably
- MAOIs and FentanylCoadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse…
- MAOIs and KetamineMAO-B inhibitors appear to increase the potency of Ketamine. MAO-A inhbitors have some negative reports associated with the combination but there…
- MAOIs and LithiumBoth raise serotonergic tone; combined use raises the risk of serotonin syndrome. This combination is sometimes used under psychiatric supervision…
- MAOIs and MescalineCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- MAOIs and MethadoneCoadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse…
- MAOIs and NBOMesMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably
- MAOIs and OpioidsCoadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse…
- MAOIs and PregabalinAdditive sedation and blood-pressure effects. Little direct data; treat as unpredictable.
Low / synergy
5Low / decrease
1Low / no synergy
6Checking more than one?
This page rates MAOIs against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open MAOIs in the checkerOther antidepressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.