Substance
What not to mix with MAOIs
AntidepressantDrug class
Also calledmaoi, nardil, phenelzine, parnate, tranylcypromine, marplan
Summary
MAOIs is checked against 40 other substances — 12 dangerous, 3 unsafe and 13 caution.
Dangerous
12- MAOIs and 5-MeO-xxTHigh risk of death or life-changing injury. Do not combine.
- MAOIs and AmphetaminesMAOIs can make amphetamines far stronger and longer-lasting, and can cause a dangerous spike in blood pressure. Do not combine.
- MAOIs and AMTAMT is already an MAOI, so adding another makes the effects very hard to predict. Do not combine.
- MAOIs and CocaineThis combination is barely documented. Do not combine.
- MAOIs and DXMTogether they carry a high risk of serotonin syndrome. Do not combine.
- MAOIs and KratomMAOIs block the breakdown of what kratom releases, risking dangerous blood pressure and serotonin reactions. Do not combine, and that includes…
- MAOIs and MDMAMAOIs can make MDMA far stronger and longer-lasting, and can cause a dangerous spike in blood pressure. Do not combine.
- MAOIs and MephedroneAn MAOI stops the body breaking down what mephedrone releases, risking a blood-pressure crisis and serotonin syndrome. Do not combine, and that…
- MAOIs and MethamphetamineAn MAOI stops the body breaking down what meth releases, risking a blood-pressure crisis and serotonin syndrome for hours. Do not combine, and that…
- MAOIs and PCPThis combination is barely documented. Do not combine.
- MAOIs and SSRIsHigh risk of death or life-changing injury. Do not combine.
- MAOIs and TramadolHigh risk of death or life-changing injury. Do not combine.
Unsafe
3- MAOIs and AlcoholMany drinks contain tyramine, which with an MAOI can push blood pressure dangerously high. Avoid this combination.
- MAOIs and DiphenhydramineThis carries a real risk of serotonin syndrome, and MAOIs can make diphenhydramine stronger and longer-lasting. Avoid this combination at…
- MAOIs and MXEMAOIs appear to make MXE stronger, and there are bad reports with some MAOIs. Avoid this combination.
Caution
13- MAOIs and 2C-T-xMAOIs can make 2C-T-x much stronger and longer-lasting in ways that are hard to predict. Take less of each than usual, and do not use alone.
- MAOIs and 2C-xMAOIs can make 2C-x much stronger and longer-lasting in ways that are hard to predict. Take less of each than usual, and do not use alone.
- MAOIs and BuprenorphineWith certain opioids, MAOIs have caused rare but severe and fatal reactions. Take less of each than usual, do not use alone, and keep naloxone nearby.
- MAOIs and CodeineWith certain opioids, MAOIs have caused rare but severe and fatal reactions. Take less of each than usual, do not use alone, and keep naloxone nearby.
- MAOIs and DOxMAOIs can make DOx much stronger and longer-lasting in ways that are hard to predict. Take less of each than usual, and do not use alone.
- MAOIs and FentanylWith certain opioids, MAOIs have caused rare but severe and fatal reactions. Take less of each than usual, do not use alone, and keep naloxone nearby.
- MAOIs and KetamineMAOIs appear to make ketamine stronger, and there are bad reports with some MAOIs. Take less ketamine than usual, and do not use alone.
- MAOIs and LithiumBoth raise serotonin, so together they risk serotonin syndrome. Do not add this recreationally.
- MAOIs and MescalineCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- MAOIs and MethadoneWith certain opioids, MAOIs have caused rare but severe and fatal reactions. Take less of each than usual, do not use alone, and keep naloxone nearby.
- MAOIs and NBOMesMAOIs can make NBOMes much stronger and longer-lasting in ways that are hard to predict. Take less of each than usual, and do not use alone.
- MAOIs and OpioidsWith certain opioids, MAOIs have caused rare but severe and fatal reactions. Take less of each than usual, do not use alone, and keep naloxone nearby.
- MAOIs and PregabalinTogether they add sedation and affect blood pressure, and there is little data. Take less of each than usual, and do not use alone.
Low / synergy
5Low / decrease
1Low / no synergy
6Checking more than one?
This page rates MAOIs against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open MAOIs in the checkerOther antidepressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.