Mixing Diphenhydramine and MAOIs
- Diphenhydramine also called
- benadryl, dph, sleep aid, zzzquil, unisom
- MAOIs also called
- maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
Unsafe
There is a significant risk of serotonin syndrome with this combination. Monoamine oxidase A inhibitors may extend and increase the anticholinergic effects of DPH. The combination increases each other’s side effects, such as drowsiness, dizziness, dry mouth, and headaches. Medical dosages are not reported to be of concern.
This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.
Can you mix Diphenhydramine and MAOIs?
Risk of serious physical or psychological harm. Not recommended under any circumstances.
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
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Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.