Mixing MAOIs and Pregabalin (Lyrica)
Caution
Together they add sedation and affect blood pressure, and there is little data. Take less of each than usual, and do not use alone.
Additive sedation and blood-pressure effects. Little direct data; treat as unpredictable.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix MAOIs and Pregabalin (Lyrica)?
MixSafe rates mixing MAOIs and Pregabalin as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.
- MAOIs also called
- maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
- FDA Warns of Respiratory Depression With Gabapentinoids. https://www.neurologylive.com/view/fda-warns-about-respiratory-depression-with-gabapentinoids
- Gabapentin and Pregabalin May Increase Risk of Respiratory Depression. University of Utah Health. https://pharmacyservices.utah.edu/alerts/2019/12/gabapentin-and-pregabalin-may-increase-risk-of-respiratory-depression
- Deaths related to the combination of pregabalin and other drugs of abuse. https://www.sciencedirect.com/science/article/abs/pii/S2352007822003316
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.