Mixing 7-OH and MAOIs

Caution

With certain opioids, MAOIs have caused rare but severe and fatal reactions.

Do this

Take less of each than usual, do not use alone, and keep naloxone nearby.

General answer for Opioids: nothing specific to these two is documented.

Where the risk isTap for why
What “Caution” means

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

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The longer explanation

Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.

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Other names
7-OH
7-hydroxymitragynine, 7-hydroxy mitragynine, 7-hydroxy, 7-oh tablets, 7oh tabs
Concentrated kratom alkaloid sold as tablets — without the leaf's ceiling on slowed breathing
MAOIs
maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
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Related combinations

7-OH withWhat not to mix with 7-OH →
MAOIs withWhat not to mix with MAOIs →
All combinations →

Can you mix 7-OH and MAOIs?

MixSafe rates mixing 7-OH and MAOIs as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to 7-OH and MAOIs is documented; this is the default for Opioids. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.