Mixing Ketamine (ket) and MAOIs
Caution
MAOIs appear to make ketamine stronger, and there are bad reports with some MAOIs. Take less ketamine than usual, and do not use alone.
MAO-B inhibitors appear to increase the potency of Ketamine. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available
The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.
Headspace vs physical riskCan you mix Ketamine (ket) and MAOIs?
MixSafe rates mixing Ketamine and MAOIs as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Ketamine also called
- ket, special k, kitty, kittens, ketty, ketalar
- MAOIs also called
- maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.