Mixing Lithium and MAOIs
Caution
Both raise serotonin, so together they risk serotonin syndrome. Do not add this recreationally.
Both raise serotonergic tone; combined use raises the risk of serotonin syndrome. This combination is sometimes used under psychiatric supervision, but not something to add recreationally.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Lithium and MAOIs?
MixSafe rates mixing Lithium and MAOIs as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.
- Lithium also called
- lithium carbonate, lithobid, mood stabilizer
- MAOIs also called
- maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
- Nayak SM et al., Johns Hopkins, 2021. https://pure.johnshopkins.edu/en/publications/classic-psychedelic-coadministration-with-lithium-but-not-lamotri/
- Ibuprofen interactions to avoid (renal lithium clearance). https://www.singlecare.com/blog/ibuprofen-interactions/
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.