Mixing Fentanyl and MAOIs
Caution
With certain opioids, MAOIs have caused rare but severe and fatal reactions. Take less of each than usual, do not use alone, and keep naloxone nearby.
Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Fentanyl and MAOIs?
MixSafe rates mixing Fentanyl and MAOIs as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to Fentanyl and MAOIs is documented; this is the default for Opioids. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.
- Fentanyl
- Synthetic — potent by micrograms, unevenly mixed
- Fentanyl also called
- fent, fentanil, carfentanil, nitazene, nitazenes, duragesic
- MAOIs also called
- maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.