Mixing MAOIs and Zolpidem (Ambien)

Low risk, increased effect

Low risk of harm, but the effects amplify each other. Doses that are fine alone can be far too much together.

Do this

Take less of each than you would alone, and let the first one kick in before you add the second.

General answer for Benzodiazepines: nothing specific to these two is documented.

What “Low risk, increased effect” means

Low risk of harm, but the effects amplify each other. Doses that are fine alone can be far too much together.

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Other names
MAOIs
maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
Zolpidem
ambien, ambien cr, stilnox, edluar, intermezzo, zolpimist
Works like a benzo, plus sleepwalking and sleep-driving with no memory of it
Also searched asmaois and Ambien, maois and ambien cr
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Related combinations

MAOIs withWhat not to mix with MAOIs →
Zolpidem withWhat not to mix with Zolpidem →
All combinations →

Can you mix MAOIs and Zolpidem (Ambien)?

MixSafe rates mixing MAOIs and Zolpidem as "Low risk, increased effect" — low risk of harm, but the effects amplify each other. Doses that are fine alone can be far too much together. No interaction specific to MAOIs and Zolpidem is documented; this is the default for Benzodiazepines. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Benzodiazepines. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.