StimulantSpeeds up brain and heart
Methylphenidate
Also called ritalin, ritalin la, concerta, focalin
Ritalin and Concerta: an ADHD stimulant that mixes much like Adderall. Shorter-acting tablets wear off in a few hours; extended-release ones last most of a day.
- Kicks in
- 20–60 min
- Lasts
- 3–12 h
- Watch for
- Heart strain
Typical times. Dose, how you take it and your body all change them.
Often mixed with
Riskiest first. Tap one for what to do.
- CaffeineCaution · BodyTwo stimulants strain the heart and can make you anxious and uncomfortable.
- AlcoholCaution · BodyAlcohol raises methylphenidate levels and turns some into a second stimulant, while the pill hides how drunk you are.
- NicotineCaution · BodyBoth raise heart rate and blood pressure, and smoking climbs on stimulants.
- CannabisCaution · MindThe stimulant can make cannabis more anxious and loop-prone.
Don't mix with
11Rated dangerous or unsafe with Methylphenidate. Tap one for why.
Other reasons
- MAOIsDangerousMAOIs can make amphetamines far stronger and longer-lasting, and can cause a dangerous spike in blood pressure.
- TramadolDangerousBoth raise the risk of a seizure, and together that risk adds up.
- 2C-T-xUnsafeStimulants make a trip more anxious and loop-prone, and together they can overwork the heart.
- 5-MeO-xxTUnsafeStimulants make a trip more anxious and loop-prone, and a psychedelic is already stimulating.
- DXMUnsafeBoth raise heart rate, and panic on this mix has led to serious heart problems.
- FentanylUnsafeThe stimulant hides how sedated you are, and the fentanyl is still working when it wears off.
- PCPUnsafeThis combination easily tips into mania.
- PregabalinUnsafeThis carries a real seizure risk, and if the amphetamine wears off first, pregabalin can slow breathing dangerously.