Mixing Mescaline (peyote) and Methylphenidate (Ritalin)

Caution

Psychedelics magnify a stimulant's focus and anxiety, making thought loops more likely.

Do this

Take less of each than usual, and do not use alone.

General answer for Amphetamines: nothing specific to these two is documented.

Where the risk isTap for why
What “Caution” means

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

How the ratings work
The longer explanation

The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops

Sources (1)

Think this is wrong, or know a better source? Send it.

Other names
Mescaline
peyote, san pedro, san-pedro, mesc, buttons
Methylphenidate
ritalin, ritalin la, concerta, focalin, dexmethylphenidate, methylin
Not an amphetamine, but mixes much like one — most answers here are Adderall's
Also searched aspeyote and Ritalin, san pedro and Ritalin, peyote and ritalin la, san pedro and ritalin la
Add a third substance in the checker

Related combinations

Mescaline withWhat not to mix with Mescaline →
Methylphenidate withWhat not to mix with Methylphenidate →
All combinations →

Can you mix Mescaline (peyote) and Methylphenidate (Ritalin)?

MixSafe rates mixing Mescaline and Methylphenidate as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to Mescaline and Methylphenidate is documented; this is the default for Amphetamines. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Amphetamines. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.