Mixing Cocaine (coke) and Methylphenidate (Ritalin)

Caution

Two stimulants strain the heart, and cocaine blunts amphetamine anyway.

Do this

Take less of each than usual, and do not use alone.

General answer for Amphetamines: nothing specific to these two is documented.

Where the risk isTap for why
What “Caution” means

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

How the ratings work
The longer explanation

This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine

Sources (1)

Think this is wrong, or know a better source? Send it.

Other names
Cocaine
coke, crack, blow, snow, yayo, yay
Methylphenidate
ritalin, ritalin la, concerta, focalin, dexmethylphenidate, methylin
Not an amphetamine, but mixes much like one — most answers here are Adderall's
Also searched ascoke and Ritalin, crack and Ritalin, coke and ritalin la, crack and ritalin la
Add a third substance in the checker

Related combinations

Cocaine withWhat not to mix with Cocaine →
Methylphenidate withWhat not to mix with Methylphenidate →
All combinations →

Can you mix Cocaine (coke) and Methylphenidate (Ritalin)?

MixSafe rates mixing Cocaine and Methylphenidate as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to Cocaine and Methylphenidate is documented; this is the default for Amphetamines. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Amphetamines. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.