Substance
What not to mix with Amphetamines (Adderall)
StimulantDrug class
Also calledadderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
Prescription and street speed — Adderall, dexamphetamine
Summary
Amphetamines is checked against 40 other substances — 3 dangerous, 7 unsafe and 23 caution.
Dangerous
3- Amphetamines and AMTHigh risk of death or life-changing injury. Do not combine.
- Amphetamines and MAOIsMAOIs can make amphetamines far stronger and longer-lasting, and can cause a dangerous spike in blood pressure. Do not combine.
- Amphetamines and TramadolBoth raise the risk of a seizure, and together that risk adds up. Do not combine.
Unsafe
7- Amphetamines and 2C-T-xStimulants make a trip more anxious and loop-prone, and together they can overwork the heart. Avoid this combination.
- Amphetamines and 5-MeO-xxTStimulants make a trip more anxious and loop-prone, and a psychedelic is already stimulating. Avoid this combination.
- Amphetamines and DOxTogether they are heavy on the body and prone to thought loops, and coming down from the amphetamine while the DOx is still going is very anxious…
- Amphetamines and DXMBoth raise heart rate, and panic on this mix has led to serious heart problems. Avoid this combination.
- Amphetamines and NBOMesTogether they overwork the heart and raise the risk of a seizure, and the trip is more loop-prone. Avoid this combination.
- Amphetamines and PCPThis combination easily tips into mania. Avoid it.
- Amphetamines and PregabalinThis carries a real seizure risk, and if the amphetamine wears off first, pregabalin can slow breathing dangerously. Avoid this combination.
Caution
23- Amphetamines and 2C-xStimulants make a trip more anxious and loop-prone, and the stimulation together can be uncomfortable. Take less of each than usual, and do not use…
- Amphetamines and AlcoholAmphetamines hide how drunk you are, so people drink far more than they mean to. If you mix them, set an hourly drink limit before you start and…
- Amphetamines and BuprenorphineThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Amphetamines and CaffeineTwo stimulants strain the heart and can make you anxious and uncomfortable. Skip the caffeine, or keep it light.
- Amphetamines and CannabisThe stimulant can make cannabis more anxious and loop-prone. Take less of each than usual.
- Amphetamines and CocaineTwo stimulants strain the heart, and cocaine blunts amphetamine anyway. Take less of each than usual, and do not use alone.
- Amphetamines and CodeineThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Amphetamines and DiphenhydramineAmphetamines can hide how confused diphenhydramine is making you, and together they strain the heart. Keep diphenhydramine to ordinary medical doses.
- Amphetamines and DMTThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Amphetamines and FentanylThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Amphetamines and GHB / GBLThe stimulant hides how sedated you are; if it wears off first, the GHB can stop your breathing. Take less of each than usual, and do not use alone.
- Amphetamines and KetamineLikely to raise blood pressure, and moving around on high doses of both risks injury. Keep doses sensible, and avoid moving around much on high doses.
- Amphetamines and KratomThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Amphetamines and LSDThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Amphetamines and MDMATogether they strain the heart, raise body temperature, and make MDMA more damaging to the brain. Take less of each than usual, take breaks, and sip…
- Amphetamines and MephedroneTwo stimulants strain the heart and brain, usually over a long session of redosing. Decide the total for the night in advance.
- Amphetamines and MescalinePsychedelics magnify a stimulant's focus and anxiety, making thought loops more likely. Take less of each than usual, and do not use alone.
- Amphetamines and MethadoneThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Amphetamines and MethamphetamineNearly the same drug, but meth lasts far longer, so adding amphetamine stretches the strain on your heart for hours. Treat it as a redose, not a new…
- Amphetamines and MushroomsThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Amphetamines and MXETogether they can race the heart, spike blood pressure, and tip into mania. Take less of each than usual, and do not use alone.
- Amphetamines and NicotineTogether they push heart rate and blood pressure higher than either alone, and you will smoke far more. Take less of each than usual.
- Amphetamines and OpioidsThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
Low / synergy
1Low / decrease
1Low / no synergy
5Checking more than one?
This page rates Amphetamines against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Amphetamines in the checkerOther stimulants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.