Mixing Amphetamines (Adderall) and Cocaine (coke)
Caution
Two stimulants strain the heart, and cocaine blunts amphetamine anyway. Take less of each than usual, and do not use alone.
This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Amphetamines (Adderall) and Cocaine (coke)?
MixSafe rates mixing Amphetamines and Cocaine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Amphetamines
- Prescription and street speed — Adderall, dexamphetamine
- Amphetamines also called
- adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
- Cocaine also called
- coke, crack, blow, snow, yayo, yay
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
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All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.