Combination

Mixing Amphetamines and Tramadol

StimulantOpioid
Amphetamines also called
adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
Tramadol also called
tram, ultram
Verdict

Dangerous

Tramadol and stimulants both increase the risk of seizures.

Risk / Physical

The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.

Can you mix Amphetamines and Tramadol?

High risk of death or life-changing injury. Do not combine.

Amphetamines
Prescription and street speed — Adderall, dexamphetamine
Tramadol
Opioid plus serotonin reuptake inhibition, and seizure risk
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

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Related combinations

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Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.