Combination

Mixing Amphetamines and Lithium

StimulantOther
Amphetamines also called
adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
Lithium also called
lithium carbonate, lithobid, mood stabilizer
Verdict

Low risk, no synergy

Lithium may be neuroprotective when taken with amphetamines and lithium may decrease the hyperactive and euphoric effects of amphetamines. Lithium may also decrease some negative side effects of amphetamines. Studies indicate this combination is safe.

Can you mix Amphetamines and Lithium?

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Amphetamines
Prescription and street speed — Adderall, dexamphetamine
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

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Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.