Mixing Amphetamines (Adderall) and MDMA (molly)
Caution
Together they strain the heart, raise body temperature, and make MDMA more damaging to the brain. Take less of each than usual, take breaks, and sip water.
This combination of stimulants will increase strain on the heart, may cause some physical discomfort, and has the chance to cause cardiovascular issues. The anxiogenic and focusing effects of stimulants can increase the chance of unpleasant thought loops and make the experience more uncomfortable, this combination raises these chances. Amphetamines will increase the neurotoxic effects of MDMA, in addition to causing further concerns of hyperthermia due to the inherent nature of the combination. It will also raise one's body temperature, also likely making the combination more neurotoxic.
This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.
Headspace vs physical riskCan you mix Amphetamines (Adderall) and MDMA (molly)?
MixSafe rates mixing Amphetamines and MDMA as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Amphetamines
- Prescription and street speed — Adderall, dexamphetamine
- Amphetamines also called
- adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
- MDMA also called
- molly, ecstasy, ecstacy, xtc, mandy, pills
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.