Substance
What not to mix with MDMA (molly)
Empathogen
Also calledmolly, ecstasy, ecstacy, xtc, mandy, pills
Summary
MDMA is checked against 40 other substances — 6 dangerous, 4 unsafe and 12 caution.
Dangerous
6- MDMA and AMTHigh risk of death or life-changing injury. Do not combine.
- MDMA and DXMHigh risk of death or life-changing injury. Do not combine.
- MDMA and LithiumTogether they carry a high risk of serotonin syndrome. Do not combine.
- MDMA and MAOIsMAOIs can make MDMA far stronger and longer-lasting, and can cause a dangerous spike in blood pressure. Do not combine.
- MDMA and MephedroneBoth raise serotonin, so together they risk serotonin syndrome, strain the heart, and make MDMA more damaging to the brain. Do not combine.
- MDMA and TramadolBoth raise the risk of a seizure, and together that risk adds up. Do not combine.
Unsafe
4- MDMA and DiphenhydramineDiphenhydramine stops you sweating, and overheating is the main way MDMA kills. Avoid this combination.
- MDMA and MethamphetamineBoth hit the same brain cells, and meth keeps up the heat and dehydration for hours after the MDMA ends. Avoid this combination.
- MDMA and PCPThis combination easily tips into mania. Avoid it.
- MDMA and PregabalinThis carries a real seizure risk, and if the MDMA wears off first, pregabalin can slow breathing dangerously. Avoid this combination at recreational…
Caution
12- MDMA and 2C-T-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- MDMA and 5-MeO-xxTSome 5-MeO drugs are unpredictable with MDMA. Take less of each than usual, and do not use alone.
- MDMA and AlcoholMDMA hides how drunk you are, and together they strain the heart and make overheating and dehydration more likely. Keep drinks few, sip water, and…
- MDMA and AmphetaminesTogether they strain the heart, raise body temperature, and make MDMA more damaging to the brain. Take less of each than usual, take breaks, and sip…
- MDMA and CaffeineCaffeine adds little to MDMA and makes it more damaging to the brain. Skip the caffeine.
- MDMA and CocaineCocaine blunts MDMA and raises the risk of a heart attack. Take less of each than usual, and do not use alone.
- MDMA and DOxThe stimulation together can be uncomfortable, and coming down from MDMA while DOx is still going is very anxious. Take less of each than usual, and…
- MDMA and GHB / GBLA lot of GHB can overwhelm you as the MDMA wears off. Take less GHB than usual, and do not use alone.
- MDMA and IbuprofenMDMA already stresses the kidneys, and ibuprofen adds to that. Rehydrate instead of taking ibuprofen ahead of time.
- MDMA and MXETaken at the same time they have caused risky serotonin reactions. Do not take them together.
- MDMA and NBOMesCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- MDMA and NicotineNicotine adds to MDMA's strain on heart rate, blood pressure and temperature, and you will smoke more. Take less of each than usual.
Low / synergy
8Low / decrease
2Low / no synergy
8Checking more than one?
This page rates MDMA against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open MDMA in the checkerEducational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.