Combination

Mixing MDMA and Opioids

EmpathogenOpioid
MDMA also called
molly, ecstasy, ecstacy, xtc, mandy, pills
Opioids also called
opiate, opiates, opioid, heroin, dope, smack
Verdict

Low risk, no synergy

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Can you mix MDMA and Opioids?

Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.

Opioids
Full agonists — heroin, oxycodone, morphine
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

MDMA withWhat not to mix with MDMA →
Opioids withWhat not to mix with Opioids →
All combinations →

Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.