Mixing Amphetamines (Adderall) and Methadone
Caution
The stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone, and keep naloxone nearby.
Stimulants increase respiration rate, which can allow for a higher dose of opiates normal . If the stimulant wears off first then the opiate may overcome the individual and cause respiratory arrest.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Amphetamines (Adderall) and Methadone?
MixSafe rates mixing Amphetamines and Methadone as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to Amphetamines and Methadone is documented; this is the default for Opioids. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.
- Amphetamines
- Prescription and street speed — Adderall, dexamphetamine
- Methadone
- Long-acting — outlasts its own effects by many hours
- Amphetamines also called
- adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
- Methadone also called
- dolophine, methadose, done
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Think this rating or note is wrong, or know a better source? Send it.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.