Combination
Mixing Benzodiazepines and Methadone
DepressantOpioid
- Benzodiazepines also called
- benzodiazepine, benzos, benzo, xanax, alprazolam, valium
- Methadone also called
- dolophine, methadose, done
Verdict
Dangerous
Additive respiratory depression against methadone's long, invisible tail. The combination is well documented in methadone-treatment mortality data and is worst in the induction period.
Risk / Physical
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Benzodiazepines and Methadone?
High risk of death or life-changing injury. Do not combine.
- Methadone
- Long-acting — outlasts its own effects by many hours
- QT prolongation with methadone. https://pmc.ncbi.nlm.nih.gov/articles/PMC2760917/
- Methadone Safety: A Clinical Practice Guideline From the American Pain Society and College on Problems of Drug Dependence, in Collaboration With the Heart Rhythm Society. https://www.sciencedirect.com/science/article/pii/S1526590014005227
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Benzodiazepines withWhat not to mix with Benzodiazepines →
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.