Mixing Amphetamines (Adderall) and Caffeine
Caution
Two stimulants strain the heart and can make you anxious and uncomfortable. Skip the caffeine, or keep it light.
This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Amphetamines (Adderall) and Caffeine?
MixSafe rates mixing Amphetamines and Caffeine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Amphetamines
- Prescription and street speed — Adderall, dexamphetamine
- Amphetamines also called
- adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
- Caffeine also called
- coffee, energy drink, espresso, pre-workout, red bull, monster
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.