Combination

Mixing Amphetamines (Adderall) and Ketamine (ket)

StimulantDissociative
Verdict

Caution

Likely to raise blood pressure, and moving around on high doses of both risks injury. Keep doses sensible, and avoid moving around much on high doses.

No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.

Risk / Headspace

The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.

Headspace vs physical risk

Can you mix Amphetamines (Adderall) and Ketamine (ket)?

MixSafe rates mixing Amphetamines and Ketamine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

Amphetamines
Prescription and street speed — Adderall, dexamphetamine
Amphetamines also called
adderall, speed, amphetamine, dexedrine, vyvanse, lisdexamfetamine
Ketamine also called
ket, special k, kitty, kittens, ketty, ketalar
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.