Mixing Methylphenidate (Ritalin) and Pregabalin (Lyrica)

Unsafe

This carries a real seizure risk, and if the amphetamine wears off first, pregabalin can slow breathing dangerously.

Do this

Avoid this combination.

General answer for Amphetamines: nothing specific to these two is documented.

Where the risk isTap for why
In an emergency, call 911911Never Use AlonePoison Control
What to do
  • Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
  • Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
  • Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
  • Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
  • Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Unsafe” means

Risk of serious physical or psychological harm. Not recommended under any circumstances.

How the ratings work
The longer explanation

There is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than normal. If amphetamines wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications.

Sources (1)

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Other names
Methylphenidate
ritalin, ritalin la, concerta, focalin, dexmethylphenidate, methylin
Not an amphetamine, but mixes much like one — most answers here are Adderall's
Pregabalin
lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
Also searched asRitalin and Lyrica, ritalin la and Lyrica, Ritalin and gabapentin, ritalin la and gabapentin
Add a third substance in the checker

Related combinations

Methylphenidate withWhat not to mix with Methylphenidate →
Pregabalin withWhat not to mix with Pregabalin →
All combinations →

Can you mix Methylphenidate (Ritalin) and Pregabalin (Lyrica)?

MixSafe rates mixing Methylphenidate and Pregabalin as "Unsafe" — risk of serious physical or psychological harm. Not recommended under any circumstances. No interaction specific to Methylphenidate and Pregabalin is documented; this is the default for Amphetamines. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Amphetamines. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.