Mixing DXM (robo) and Xylazine (tranq)
Unsafe
High-dose DXM and xylazine both impair breathing, and vomiting while sedated is the danger.
Do this
Avoid this combination, and put anyone who passes out on their side.
Where the risk isTap for why
What to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Unsafe” means
Risk of serious physical or psychological harm. Not recommended under any circumstances.
How the ratings workThe longer explanation
At recreational doses DXM impairs breathing and coordination on its own; xylazine adds deep sedation, a slow heart and low blood pressure. Vomiting while sedated is the usual danger.
Sources (3)
- What You Should Know About Xylazine. CDCcdc.gov
- Ruiz-Colón K et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014sciencedirect.com
- Friedman J et al. Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov
Think this is wrong, or know a better source? Send it.
Other names
- DXM
- robo, robitussin, robotussin, syrup, dex, cough syrup
- Cold medicines often add acetaminophen or an antihistamine — check the label
- Xylazine
- tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine
- Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither
Also searched asrobo and tranq, robitussin and tranq, robo and tranq dope, robitussin and tranq dope
Related combinations
DXM withWhat not to mix with DXM →
Xylazine with
All combinations →- KetamineDangerous
- MXEDangerous
- AlcoholDangerous
- BenzodiazepinesDangerous
- ZolpidemDangerous
- GHB / GBLDangerous
Can you mix DXM (robo) and Xylazine (tranq)?
MixSafe rates mixing DXM and Xylazine as "Unsafe" — risk of serious physical or psychological harm. Not recommended under any circumstances. Source: MixSafe research. Educational information, not medical advice.