Substance
What not to mix with Nitrous Oxide
Dissociative
Also callednitrous, n2o, nos, laughing gas, whippits, whippets
Summary
Nitrous Oxide is checked against 40 other substances — 11 caution.
Caution
11- Nitrous Oxide and AlcoholBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Nitrous Oxide and BuprenorphineBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Nitrous Oxide and CodeineBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Nitrous Oxide and DiphenhydramineAdditive dissociation and disorientation, with a raised risk of falling. Diphenhydramine's sedation makes the loss of coordination last well past the…
- Nitrous Oxide and FentanylBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Nitrous Oxide and GHB / GBLBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Nitrous Oxide and KratomBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Nitrous Oxide and MethadoneBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Nitrous Oxide and OpioidsBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Nitrous Oxide and PregabalinBoth substances potentiate the ataxia and sedation caused by the other, and may increase the risk of loss of consciousness at higher dosages. While…
- Nitrous Oxide and TramadolBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
Low / synergy
20Low / decrease
1Low / no synergy
8Checking more than one?
This page rates Nitrous Oxide against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Nitrous Oxide in the checkerOther dissociatives
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.