Substance
What not to mix with Nitrous Oxide (nos)
Dissociative
Also callednitrous, n2o, nos, laughing gas, whippits, whippets
Summary
Nitrous Oxide is checked against 40 other substances — 11 caution.
Caution
11- Nitrous Oxide and AlcoholEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual. If someone passes out, put them on…
- Nitrous Oxide and BuprenorphineEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, do not use alone, and keep naloxone…
- Nitrous Oxide and CodeineEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, do not use alone, and keep naloxone…
- Nitrous Oxide and DiphenhydramineTogether they add disorientation and the risk of falling, which lasts well past the nitrous. Take less of each than usual, and do not use alone.
- Nitrous Oxide and FentanylEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, do not use alone, and keep naloxone…
- Nitrous Oxide and GHB / GBLEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, and do not use alone.
- Nitrous Oxide and KratomEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, do not use alone, and keep naloxone…
- Nitrous Oxide and MethadoneEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, do not use alone, and keep naloxone…
- Nitrous Oxide and OpioidsEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, do not use alone, and keep naloxone…
- Nitrous Oxide and PregabalinEach makes the other stronger, so passing out and injury are more likely, and heavy nitrous use raises the risk of a seizure. Take less of each than…
- Nitrous Oxide and TramadolEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, and do not use alone.
Low / synergy
20Low / decrease
1Low / no synergy
8Checking more than one?
This page rates Nitrous Oxide against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Nitrous Oxide in the checkerOther dissociatives
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.