Mixing Nitrous Oxide (nos) and Xylazine (tranq)
Caution
Both can knock you out, and nitrous cuts oxygen while xylazine slows breathing.
Do this
Sit down, keep it brief, and don't use alone.
Where the risk isTap for why
What “Caution” means
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
How the ratings workThe longer explanation
Both can knock you out, and nitrous displaces oxygen for the minutes it lasts while xylazine is already slowing breathing. Sit down, keep it brief, and do not use alone.
Sources (3)
- What You Should Know About Xylazine. CDCcdc.gov
- Ruiz-Colón K et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014sciencedirect.com
- Friedman J et al. Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov
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Other names
- Nitrous Oxide
- nitrous, n2o, nos, laughing gas, whippits, whippets
- Xylazine
- tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine
- Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither
Also searched asnos and tranq, laughing gas and tranq, nos and tranq dope, laughing gas and tranq dope
Related combinations
Nitrous Oxide withWhat not to mix with Nitrous Oxide →
Xylazine with
All combinations →- KetamineDangerous
- MXEDangerous
- AlcoholDangerous
- BenzodiazepinesDangerous
- ZolpidemDangerous
- GHB / GBLDangerous
Can you mix Nitrous Oxide (nos) and Xylazine (tranq)?
MixSafe rates mixing Nitrous Oxide and Xylazine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.