Combination

Mixing Benzodiazepines and Nitrous Oxide

DepressantDissociative
Benzodiazepines also called
benzodiazepine, benzos, benzo, xanax, alprazolam, valium
Nitrous Oxide also called
nitrous, n2o, nos, laughing gas, whippits, whippets
Verdict

Low risk, decreased effect

Low risk of harm from the combination, but one substance is expected to blunt the other. Redosing to chase the missing effect is the usual way this turns dangerous.

Can you mix Benzodiazepines and Nitrous Oxide?

Low risk of harm from the combination, but one substance is expected to blunt the other. Redosing to chase the missing effect is the usual way this turns dangerous.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

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Rated low / decrease. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.