Mixing Nitrous Oxide (nos) and Zolpidem (Ambien)
Caution
Both sedate, and nitrous on top of a benzo deepens it fast: passing out, falling and memory gaps are all likely.
Sit or lie down, take less of each, and do not use alone.
General answer for Benzodiazepines: nothing specific to these two is documented.
What “Caution” means
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
How the ratings workThe longer explanation
Both sedate, and nitrous adds to whatever sedation is already there: in dentistry, nitrous on top of a sedative pill counts as a deeper level of sedation that needs more monitoring. Expect to be far more out of it than either alone, with a real chance of passing out, falling, or not remembering. Sit or lie down, and do not do this alone.
Sources (1)
- Guidelines for the Use of Sedation and General Anesthesia by Dentists. American Dental Association, 2016dentistry.ky.gov
Think this is wrong, or know a better source? Send it.
Other names
- Nitrous Oxide
- nitrous, n2o, nos, laughing gas, whippits, whippets
- Zolpidem
- ambien, ambien cr, stilnox, edluar, intermezzo, zolpimist
- Works like a benzo, plus sleepwalking and sleep-driving with no memory of it
Related combinations
- AlcoholDangerous
- XylazineDangerous
- GHB / GBLDangerous
- PregabalinDangerous
- OpioidsDangerous
- FentanylDangerous
Can you mix Nitrous Oxide (nos) and Zolpidem (Ambien)?
MixSafe rates mixing Nitrous Oxide and Zolpidem as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to Nitrous Oxide and Zolpidem is documented; this is the default for Benzodiazepines. Source: MixSafe research. Educational information, not medical advice.
This is a class-level answer, inherited from Benzodiazepines. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.