Mixing 7-OH and Nitrous Oxide (nos)
Caution
Each makes the other stronger, so you can lose balance or pass out without warning.
Take less of each than usual, do not use alone, and keep naloxone nearby.
General answer for Opioids: nothing specific to these two is documented.
What “Caution” means
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
How the ratings workThe longer explanation
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
Sources (1)
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Other names
- 7-OH
- 7-hydroxymitragynine, 7-hydroxy mitragynine, 7-hydroxy, 7-oh tablets, 7oh tabs
- Concentrated kratom alkaloid sold as tablets — without the leaf's ceiling on slowed breathing
- Nitrous Oxide
- nitrous, n2o, nos, laughing gas, whippits, whippets
Related combinations
Can you mix 7-OH and Nitrous Oxide (nos)?
MixSafe rates mixing 7-OH and Nitrous Oxide as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to 7-OH and Nitrous Oxide is documented; this is the default for Opioids. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.