Mixing Nitrous Oxide (nos) and Tianeptine (gas station heroin)

Caution

Each makes the other stronger, so you can lose balance or pass out without warning.

Do this

Take less of each than usual, do not use alone, and keep naloxone nearby.

General answer for Opioids: nothing specific to these two is documented.

Where the risk isTap for why
What “Caution” means

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

How the ratings work
The longer explanation

Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.

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Other names
Nitrous Oxide
nitrous, n2o, nos, laughing gas, whippits, whippets
Tianeptine
gas station heroin, tianaa, zaza red, neptune's fix, pegasus, td red
Sold as a supplement — at the doses people take, a full opioid
Also searched asnos and gas station heroin, laughing gas and gas station heroin, nos and tianaa, laughing gas and tianaa
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Related combinations

Nitrous Oxide withWhat not to mix with Nitrous Oxide →
Tianeptine withWhat not to mix with Tianeptine →
All combinations →

Can you mix Nitrous Oxide (nos) and Tianeptine (gas station heroin)?

MixSafe rates mixing Nitrous Oxide and Tianeptine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to Nitrous Oxide and Tianeptine is documented; this is the default for Opioids. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.