Mixing Codeine and Nitrous Oxide
- Codeine also called
- lean, purple drank, co-codamol, dihydrocodeine
- Nitrous Oxide also called
- nitrous, n2o, nos, laughing gas, whippits, whippets
Caution
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.
Can you mix Codeine and Nitrous Oxide?
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.
- Codeine
- Weak, but metabolised unpredictably between people
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.