Combination
Mixing Benzodiazepines and Codeine
DepressantOpioid
- Benzodiazepines also called
- benzodiazepine, benzos, benzo, xanax, alprazolam, valium
- Codeine also called
- lean, purple drank, co-codamol, dihydrocodeine
Verdict
Dangerous
Additive respiratory depression, made worse by codeine's unpredictable conversion. A dose that was fine last time can convert very differently alongside a drug that also alters liver metabolism.
Risk / Physical
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Benzodiazepines and Codeine?
High risk of death or life-changing injury. Do not combine.
- Codeine
- Weak, but metabolised unpredictably between people
- Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism. NEJM. https://www.nejm.org/doi/full/10.1056/NEJMoa041888
- Codeine Therapy and CYP2D6 Genotype. Medical Genetics Summaries, NCBI. https://www.ncbi.nlm.nih.gov/books/NBK100662/
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Benzodiazepines withWhat not to mix with Benzodiazepines →
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.