Combination

Mixing Codeine and MXE

OpioidDissociative
Codeine also called
lean, purple drank, co-codamol, dihydrocodeine
MXE also called
methoxetamine
Verdict

Dangerous

This combination can potentiate the effects of the opioid

Risk / Physical + headspace

This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.

Can you mix Codeine and MXE?

High risk of death or life-changing injury. Do not combine.

This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.

Codeine
Weak, but metabolised unpredictably between people
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

Open this in the checker

Related combinations

Codeine withWhat not to mix with Codeine →
MXE withWhat not to mix with MXE →
All combinations →

Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.