Mixing Lithium and SSRIs (antidepressants)
Low risk, no synergy
This interaction is used in medical settings without reported issues. If this combination is taken, caution would be recommended if any other drugs are planned to be taken on top of these that may have serotonergic activity.
Can you mix Lithium and SSRIs (antidepressants)?
MixSafe rates mixing Lithium and SSRIs as "Low risk, no synergy" — neither substance is expected to meaningfully change the other. Both still carry their own individual risks. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Lithium also called
- lithium carbonate, lithobid, mood stabilizer
- SSRIs also called
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.