Mixing Lithium and Methadone
- Lithium also called
- lithium carbonate, lithobid, mood stabilizer
- Methadone also called
- dolophine, methadose, done
Caution
No direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that lithium with tramadol specifically is rated dangerous because of tramadol's serotonergic activity.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Lithium and Methadone?
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.
- Methadone
- Long-acting — outlasts its own effects by many hours
- Nayak SM et al., Johns Hopkins, 2021. https://pure.johnshopkins.edu/en/publications/classic-psychedelic-coadministration-with-lithium-but-not-lamotri/
- Ibuprofen interactions to avoid (renal lithium clearance). https://www.singlecare.com/blog/ibuprofen-interactions/
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.