Mixing Lithium and Methadone
Caution
Together they add sedation, and dehydration can push lithium levels up. Keep up water, and keep naloxone nearby.
No direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that lithium with tramadol specifically is rated dangerous because of tramadol's serotonergic activity.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Lithium and Methadone?
MixSafe rates mixing Lithium and Methadone as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to Lithium and Methadone is documented; this is the default for Opioids. Source: MixSafe research. Educational information, not medical advice.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.
- Methadone
- Long-acting — outlasts its own effects by many hours
- Lithium also called
- lithium carbonate, lithobid, mood stabilizer
- Methadone also called
- dolophine, methadose, done
- Nayak SM et al., Johns Hopkins, 2021. https://pure.johnshopkins.edu/en/publications/classic-psychedelic-coadministration-with-lithium-but-not-lamotri/
- Ibuprofen interactions to avoid (renal lithium clearance). https://www.singlecare.com/blog/ibuprofen-interactions/
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.