Mixing Lithium and Tianeptine (gas station heroin)
Caution
Together they add sedation, and dehydration can push lithium levels up.
Keep up water, and keep naloxone nearby.
General answer for Opioids: nothing specific to these two is documented.
What “Caution” means
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
How the ratings workThe longer explanation
No direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that lithium with tramadol specifically is rated dangerous because of tramadol's serotonergic activity.
Sources (2)
- Nayak SM et al., Johns Hopkins, 2021pure.johnshopkins.edu
- Ibuprofen interactions to avoid (renal lithium clearance)singlecare.com
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Other names
- Lithium
- lithium carbonate, lithobid, mood stabilizer
- Tianeptine
- gas station heroin, tianaa, zaza red, neptune's fix, pegasus, td red
- Sold as a supplement — at the doses people take, a full opioid
Related combinations
Can you mix Lithium and Tianeptine (gas station heroin)?
MixSafe rates mixing Lithium and Tianeptine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to Lithium and Tianeptine is documented; this is the default for Opioids. Source: MixSafe research. Educational information, not medical advice.
This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.