Mixing 5-MeO-xxT (5-MeO-DMT) and Diphenhydramine (Benadryl)
Caution
Delirium on top of a short, intense trip is disorienting and hard to manage. Take less of each than usual, and do not use alone.
Deliriant effects combined with an intense, short psychedelic make for a disorienting and hard-to-manage experience.
The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.
Headspace vs physical riskCan you mix 5-MeO-xxT (5-MeO-DMT) and Diphenhydramine (Benadryl)?
MixSafe rates mixing 5-MeO-xxT and Diphenhydramine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.
- 5-MeO-xxT also called
- 5-meo-dmt, 5-meo-mipt, 5-meo-dipt, foxy, toad, bufo
- Diphenhydramine also called
- benadryl, dph, sleep aid, zzzquil, unisom, doxylamine
- Serotonin Syndrome: Mechanisms, Diagnosis, High-Risk Interactions. https://psychopharmacologyinstitute.com/publication/serotonin-syndrome-mechanisms-diagnosis-high-risk-interactions-and-management/
- Diphenhydramine interaction profile. Drugs.com. https://www.drugs.com/drug-interactions/melatonin.html
Think this rating or note is wrong, or know a better source? Send it.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.