Substance
What not to mix with LSD
Psychedelic
Also calledacid, lsd-25, cid, lucy, tabs, blotter
Summary
LSD is checked against 40 other substances — 1 dangerous, 1 unsafe and 7 caution.
Dangerous
1Unsafe
1Caution
7- LSD and AmphetaminesStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- LSD and CannabisCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- LSD and CocaineStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- LSD and DiphenhydramineAt 25-50mg, DPH may assist with side effects of the LSD such as nausea and anxiety. At higher dosages, the combination of a deliriant (DPH) and LSD…
- LSD and MephedroneThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops, in addition to the possible negative side effects…
- LSD and MethamphetamineStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- LSD and PregabalinCaution should be given due to LSD’s stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the…
Low / synergy
15Low / decrease
5Low / no synergy
11Checking more than one?
This page rates LSD against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open LSD in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.