Substance
What not to mix with LSD (acid)
Psychedelic
Also calledacid, lsd-25, cid, lucy, tabs, blotter
Summary
LSD is checked against 40 other substances — 1 dangerous, 1 unsafe and 7 caution.
Dangerous
1Unsafe
1Caution
7- LSD and AmphetaminesThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- LSD and CannabisCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- LSD and CocaineThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- LSD and DiphenhydramineBeyond an ordinary 25–50 mg dose of diphenhydramine, LSD makes its delirium worse and adds heart strain. Keep diphenhydramine to that dose.
- LSD and MephedroneThe stimulant makes a trip more anxious and loop-prone, and together they can overwork the heart. Take less of each than usual, and do not use alone.
- LSD and MethamphetamineThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- LSD and PregabalinLSD is stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of each than…
Low / synergy
15Low / decrease
5Low / no synergy
11Checking more than one?
This page rates LSD against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open LSD in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.