Mixing LSD (acid) and SSRIs (antidepressants)
Low risk, decreased effect
Low risk of harm from the combination, but one substance is expected to blunt the other. Redosing to chase the missing effect is the usual way this turns dangerous.
Can you mix LSD (acid) and SSRIs (antidepressants)?
MixSafe rates mixing LSD and SSRIs as "Low risk, decreased effect" — low risk of harm from the combination, but one substance is expected to blunt the other. Redosing to chase the missing effect is the usual way this turns dangerous. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- LSD also called
- acid, lsd-25, cid, lucy, tabs, blotter
- SSRIs also called
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated low / decrease. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.