Substance
What not to mix with DMT
Psychedelic
Also calledn,n-dmt, dimethyltryptamine, changa, deems, dimitri
Summary
DMT is checked against 40 other substances — 1 dangerous, 1 unsafe and 5 caution.
Dangerous
1Unsafe
1Caution
5- DMT and AmphetaminesThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- DMT and CannabisCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- DMT and CocaineThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- DMT and DiphenhydramineBeyond an ordinary 25–50 mg dose of diphenhydramine, DMT makes its delirium worse and injury more likely. Keep diphenhydramine to that dose.
- DMT and MethamphetamineThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
Low / synergy
18Low / decrease
4Low / no synergy
11Checking more than one?
This page rates DMT against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open DMT in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.