Mixing DMT and Xylazine (tranq)
Caution
Nobody has studied this pair. Xylazine alone causes deep sedation and slowed breathing that naloxone can't reverse, and it nearly always comes cut into fentanyl.
Don't use alone.
What “Caution” means
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
How the ratings workThe longer explanation
Nobody has studied xylazine with this, and no specific interaction is known. It is rated Caution rather than low risk because xylazine is barely studied in people and dangerous on its own: deep sedation, slowed breathing, a slow heart and low blood pressure, none of which naloxone reverses. It is almost never taken on purpose; it comes cut into fentanyl, so if you have been exposed to it, look at the fentanyl pair too, and do not use alone.
Sources (3)
- What You Should Know About Xylazine. CDCcdc.gov
- Ruiz-Colón K et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014sciencedirect.com
- Friedman J et al. Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov
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Related combinations
- LithiumDangerous
- TramadolUnsafe
- AmphetaminesCaution
- MethamphetamineCaution
- MethylphenidateCaution
- CocaineCaution
- KetamineDangerous
- MXEDangerous
- AlcoholDangerous
- BenzodiazepinesDangerous
- ZolpidemDangerous
- GHB / GBLDangerous
Can you mix DMT and Xylazine (tranq)?
MixSafe rates mixing DMT and Xylazine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.