Substance
What not to mix with Mushrooms
Psychedelic
Also calledshrooms, psilocybin, psilocybin mushrooms, mushroom, psylocybin, caps
Summary
Mushrooms is checked against 40 other substances — 1 dangerous, 1 unsafe and 5 caution.
Dangerous
1Unsafe
1Caution
5- Mushrooms and AmphetaminesStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Mushrooms and CannabisCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Mushrooms and CocaineStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Mushrooms and DiphenhydramineAt 25-50mg, DPH may assist with side effects of the psilocybin such as nausea and anxiety. At higher dosages, the combination of a deliriant (DPH)…
- Mushrooms and MethamphetamineStimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
Low / synergy
18Low / decrease
4Low / no synergy
11Checking more than one?
This page rates Mushrooms against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Mushrooms in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.