Substance
What not to mix with Mushrooms (shrooms)
Psychedelic
Also calledshrooms, psilocybin, psilocybin mushrooms, mushroom, psylocybin, caps
Summary
Mushrooms is checked against 40 other substances — 1 dangerous, 1 unsafe and 5 caution.
Dangerous
1Unsafe
1Caution
5- Mushrooms and AmphetaminesThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Mushrooms and CannabisCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Mushrooms and CocaineThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Mushrooms and DiphenhydramineBeyond an ordinary 25–50 mg dose of diphenhydramine, mushrooms make its delirium worse and injury more likely. Keep diphenhydramine to that dose.
- Mushrooms and MethamphetamineThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
Low / synergy
18Low / decrease
4Low / no synergy
11Checking more than one?
This page rates Mushrooms against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Mushrooms in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.