Substance
What not to mix with AMT
Psychedelic
Also calledalpha-methyltryptamine, alphamethyltryptamine, indopan, monase
Summary
AMT is checked against 40 other substances — 17 dangerous and 6 caution.
Dangerous
17- AMT and 2C-T-xHigh risk of death or life-changing injury. Do not combine.
- AMT and 2C-xHigh risk of death or life-changing injury. Do not combine.
- AMT and 5-MeO-xxTHigh risk of death or life-changing injury. Do not combine.
- AMT and AmphetaminesHigh risk of death or life-changing injury. Do not combine.
- AMT and CocaineHigh risk of death or life-changing injury. Do not combine.
- AMT and DOxHigh risk of death or life-changing injury. Do not combine.
- AMT and DXMHigh risk of death or life-changing injury. Do not combine.
- AMT and LithiumLithium with psychedelics carries a well-documented seizure risk. Do not combine.
- AMT and MAOIsAMT is already an MAOI, so adding another makes the effects very hard to predict. Do not combine.
- AMT and MDMAHigh risk of death or life-changing injury. Do not combine.
- AMT and MescalineHigh risk of death or life-changing injury. Do not combine.
- AMT and MethamphetamineHigh risk of death or life-changing injury. Do not combine.
- AMT and MXEHigh risk of death or life-changing injury. Do not combine.
- AMT and NBOMesHigh risk of death or life-changing injury. Do not combine.
- AMT and PCPHigh risk of death or life-changing injury. Do not combine.
- AMT and SSRIsHigh risk of death or life-changing injury. Do not combine.
- AMT and TramadolHigh risk of death or life-changing injury. Do not combine.
Caution
6- AMT and AlcoholBoth act broadly on the brain, so the mix is unpredictable. Take less of each than usual, and do not use alone.
- AMT and CaffeineCaffeine's anxiety is harder to manage while tripping, and together they can be physically uncomfortable. Keep caffeine light.
- AMT and CannabisCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- AMT and DiphenhydramineTogether they add confusion, and diphenhydramine stops you sweating while AMT heats you up. Take less of each than usual, and do not use alone.
- AMT and MephedroneBoth release serotonin, so together they carry a real risk of serotonin syndrome and heart strain. Take less of each than usual, and do not use alone.
- AMT and PregabalinThe sedation hides how much AMT you have taken, and the mix is unpredictable. Take less of each than usual, and do not use alone.
Low / synergy
5Low / decrease
2Low / no synergy
10Checking more than one?
This page rates AMT against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open AMT in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.