Mixing Mescaline (peyote) and Pregabalin (Lyrica)
Caution
Mescaline is stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of each than usual, and do not use alone.
Caution should be given due to mescaline’s stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the vasoconstriction, anxiety, and other side effects of mescaline. Additionally, Pregabalin may increase mescaline’s inhibition and risk of injury.
The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.
Headspace vs physical riskCan you mix Mescaline (peyote) and Pregabalin (Lyrica)?
MixSafe rates mixing Mescaline and Pregabalin as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Mescaline also called
- peyote, san pedro, san-pedro, mesc, buttons
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.