Mixing Pregabalin (Lyrica) and SSRIs (antidepressants)
Caution
Together they cause more drowsiness and dizziness than people expect from two prescriptions. Expect to be more impaired than on either alone.
Additive sedation and dizziness. No serotonergic interaction, but the combined impairment is more than people expect from a prescribed pair.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Pregabalin (Lyrica) and SSRIs (antidepressants)?
MixSafe rates mixing Pregabalin and SSRIs as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
- SSRIs also called
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
- FDA Warns of Respiratory Depression With Gabapentinoids. https://www.neurologylive.com/view/fda-warns-about-respiratory-depression-with-gabapentinoids
- Gabapentin and Pregabalin May Increase Risk of Respiratory Depression. University of Utah Health. https://pharmacyservices.utah.edu/alerts/2019/12/gabapentin-and-pregabalin-may-increase-risk-of-respiratory-depression
- Deaths related to the combination of pregabalin and other drugs of abuse. https://www.sciencedirect.com/science/article/abs/pii/S2352007822003316
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.