Mixing Pregabalin and Tramadol
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba
- Tramadol also called
- tram, ultram
Unsafe
There is a significant risk of seizures. Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and unconsciousness. The interaction will cause greater inhibition and risk of injury. If the user falls unconscious it is strongly recommended to put them into the recovery position and monitor breathing. Medical dosages are not reported to be a concern.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Pregabalin and Tramadol?
Risk of serious physical or psychological harm. Not recommended under any circumstances.
- Tramadol
- Opioid plus serotonin reuptake inhibition, and seizure risk
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.