Mixing Pregabalin (Lyrica) and Tramadol
Unsafe
Together they raise the seizure risk and can knock you out. Avoid this combination at recreational doses. If someone passes out, put them on their side and watch their breathing.
There is a significant risk of seizures. Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and unconsciousness. The interaction will cause greater inhibition and risk of injury. If the user falls unconscious it is strongly recommended to put them into the recovery position and monitor breathing. Medical dosages are not reported to be a concern.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskWhat to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Give naloxone (Narcan) if you have it.It is sold over the counter in every US state and does no harm if opioids turn out not to be involved.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
Can you mix Pregabalin (Lyrica) and Tramadol?
MixSafe rates mixing Pregabalin and Tramadol as "Unsafe" — risk of serious physical or psychological harm. Not recommended under any circumstances. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Tramadol
- Opioid plus serotonin reuptake inhibition, and seizure risk
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
- Tramadol also called
- tram, ultram
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.