Mixing MXE and Pregabalin (Lyrica)
Caution
Each can make the other's nausea, dizziness and blackouts worse, and more than low doses raise the risk of a seizure. Take less of each than usual, and do not use alone.
Pregabalin and MXE may synergize and increase each other’s negative side effects such as nausea, dizziness, and loss of consciousness. Caution is advised for anything above low dosages due to seizure concerns, and all dosages for individuals with higher risk seizure profiles and or behavior.
The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.
Headspace vs physical riskCan you mix MXE and Pregabalin (Lyrica)?
MixSafe rates mixing MXE and Pregabalin as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- MXE also called
- methoxetamine
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.