Combination
Mixing Melatonin and Pregabalin (Lyrica)
DepressantDepressant
Verdict
Low risk, increased effect
Additive sedation and drowsiness.
Can you mix Melatonin and Pregabalin (Lyrica)?
MixSafe rates mixing Melatonin and Pregabalin as "Low risk, increased effect" — low risk of harm, but the effects amplify each other. Doses that are fine alone can be far too much together. Source: MixSafe research. Educational information, not medical advice.
- Melatonin also called
- sleep hormone, circadin
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
- Melatonin Interactions Checker. Drugs.com. https://www.drugs.com/drug-interactions/melatonin.html
- Melatonin + Xanax: Can You Take Them Together? https://www.drugs.com/drug-interactions/melatonin-with-xanax-1548-0-133-54.html
- Melatonin and SSRIs. https://ubiehealth.com/doctors-note/melatonin-ssris-drug-interaction-safety-caution-5851q1
Think this rating or note is wrong, or know a better source? Send it.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Melatonin withWhat not to mix with Melatonin →
Pregabalin withWhat not to mix with Pregabalin →
Rated low / synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.