Mixing Diphenhydramine and Pregabalin
- Diphenhydramine also called
- benadryl, dph, sleep aid, zzzquil, unisom
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba
Unsafe
There is a significant risk of seizures from this combination. The combination is likely to increase each other’s negative side effects, such as nausea, dizziness, and loss of consciousness. At higher dosages, pregabalin is likely to increase diphenhydramine’s deliriant effects, inhibition, and risk of injury. Medical dosages are not reported to be a concern.
This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.
Can you mix Diphenhydramine and Pregabalin?
Risk of serious physical or psychological harm. Not recommended under any circumstances.
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
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Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.